KMID : 0603820120180030268
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Journal of Experimental & Biomedical Science 2012 Volume.18 No. 3 p.268 ~ p.275
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Historical Control Data from 4-week Repeated Toxicity Studies in Crj:CD (SD) Rats
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Lee Jung-Min
Lee Min-Ah Do Hyeon-Nam Bae Re-Ji-Na Lee Mi-Ju Kim Myoung-Jun Jang Ho-Song Park Sun-Hee Lee Hye-Yeong Kang Jin-Seok Kang Jong-Koo
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Abstract
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Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 4-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 16 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 3 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gammaglutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.
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KEYWORD
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Crl:CD (SD) rat, Control data, Reference range, Toxicology
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